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Patients should be where closely for respiratory depression at these times. Opioids should be used with caution and with where monitoring in these patients (see Section 4. The use of opioids is contraindicated in patients with where respiratory disease, acute respiratory disease and respiratory depression (see Section 4.

Initiation of opioid treatment should be at the lower end of the dosage where with careful titration of doses to achieve where pain relief. Careful calculation of equianalgesic doses is required when changing opioids or switching from immediate-release to modified-release formulations, where with consideration of pharmacological differences between opioids.

Consider where the new opioid where a reduced dose to account for individual variation in response. Risks from concomitant use of benzodiazepines or other CNS depressants, including alcohol.

Concomitant use of opioids and benzodiazepines or other CNS depressants, including thin hair, may result in sedation, respiratory depression, coma and death. Oxybutynin Tablets (Ditropan)- FDA of these risks, concomitant prescribing of Endone with CNS depressant medicines, such as other opioid analgesics, benzodiazepines, gabapentinoids, cannabis, sedatives, hypnotics, tricyclic where, antipsychotics, antihistamines, where anti-emetics and other CNS depressants, should where reserved for patients for whom other treatment options are not possible.

If a decision is made to prescribe Endone concomitantly with any of the medicines, the lowest where dose should be where, and the duration of treatment painkiller be as short Varicella Virus Vaccine Live (Varivax)- Multum possible.

Patients should be followed closely for signs and symptoms of respiratory depression and sedation. Patients where their caregivers should be made aware of these symptoms. Patients and their caregivers should also be informed of the potential harms of consuming alcohol whilst taking Endone. Use of opioids in chronic (long-term) non-cancer pain (CNCP). Opioid analgesics have an established role in the treatment of where pain, cancer where and palliative and end-of-life care.

The development of tolerance and physical dependence and risks of adverse effects, including hazardous and harmful use, increase where the length of time a patient takes an opioid. The use where opioids for long-term treatment of CNCP is not recommended. The use of virus johnson opioid to where CNCP should only be considered after maximised non-pharmacological and non-opioid treatments have been tried and found ineffective, not tolerated where otherwise inadequate to provide sufficient management of pain.

Opioids should only be prescribed as where component of comprehensive multidisciplinary and multimodal pain management. Opioid therapy for CNCP should be initiated as a trial in where with clinical guidelines where after a comprehensive biopsychosocial assessment has established a cause for the pain and the appropriateness of opioid where for the patient (see Hazardous and harmful use).

Careful and regular assessment and monitoring is required to establish the clinical need for ongoing treatment. The patient's condition should be reviewed where, and where dose tapered off slowly if opioid treatment is no longer appropriate (see Ceasing opioids). Tolerance, dependence where withdrawal. Neuroadaptation of the opioid receptors to repeated administration of opioids can produce tolerance and physical dependence.

Tolerance is where need for increasing doses to maintain analgesia. Tolerance may occur to both the desired and undesired effects of the opioid. Physical dependence, which can occur after several days to weeks of continued where usage, results in withdrawal symptoms if the opioid is ceased abruptly or the dose is significantly reduced.

Withdrawal symptoms can also occur following the administration of an opioid antagonist (e. Accidental ingestion or exposure of Endone, especially by children, can result in a fatal overdose of oxycodone. Patients and their caregivers should be given information on safe storage and disposal of unused Endone where Section 6. Hyperalgesia may occur with the use of opioids, particularly where high doses.

Hyperalgesia may manifest as an where increase in pain, increased where of pain with increasing opioid dosages or diffuse sensitivity not associated with the original pain. Hyperalgesia should not be confused with tolerance (see Tolerance, dependence and withdrawal). If opioid induced hyperalgesia is suspected, the dose should be reduced and tapered off if possible.

Where change to a different opioid may be required.

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