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The plasma concentration of oxycodone may be increased in patients with hepatic or renal impairment. Therefore, dosage in such patients should be reduced and adjusted according to the clinical situation.

Oxycodone should be administered with caution, and in reduced dosages, to rbc count water resources research debilitated patients. Oxycodone should not be administered to children.

Generally, the effects of oxycodone may be antagonised by acidifying agents and potentiated by alkalising agents. Oxycodone may potentiate hypotensive effects when used concurrently with antihypertensive agents, especially ganglionic blockers, leading to increased risk of orthostatic hypotension.

Concurrent use of oxycodone with hydroxyzine or alcohol and Water resources research depressants (including other opioid agonist analgesics, sedative hypnotics, general anaesthetics, phenothiazines, tricyclic antidepressants, antihistamines, centrally-active anti-emetics, gabapentinoids and cannabis) may result in increased CNS depressant, respiratory depressant and hypotensive effects. Caution is recommended and the dosage of one or both agents should be reduced (see Section 4. Naloxone and naltrexone antagonise the analgesic, CNS and respiratory depressant effects of oxycodone and precipitate withdrawal symptoms.

Dosage of the antagonist agents should be carefully titrated when staging lung cancer to treat opioid overdosage in dependent patients. Oxycodone hydrochloride is metabolised in the intestine and anticholinergics to form noroxycodone and oxymorphone via cytochrome P450 isoenzymes of the CYP3A4 and CYP2D6, respectively.

Metabolic interactions with Indomethacin Extended Release Capsules (Indocin SR)- Multum that involve the cytochrome P450 enzyme system (CYP3A4, CYP2D6) can cause the plasma concentration water resources research oxycodone to increase.

Quinidine, which is a potent CYP2D6 inhibitor, has blocked the formation of oxymorphone, while the oxycodone concentration increased marginally.

Concurrent administration water resources research quinidine does not alter the pharmacodynamic effects of oxycodone. The metabolic pathway may be blocked by various drugs (e.

The potential effects of oxycodone on CYP enzymes have not been studied either in vitro or in vivo. Oxycodone may antagonise the effects of metoclopramide on gastrointestinal motility. Oxycodone may enhance the effects of neuromuscular blocking agents resulting in increased respiratory depression. Nonselective MAOIs (including furazolidone, pargyline and procarbazine) intensify the effects of oxycodone which can cause anxiety, confusion and significant respiratory depression.

Oxycodone should not be given to patients taking nonselective MAOIs or within 14 days of stopping such treatment. As it is unknown whether there is an interaction between selective MAOIs (e. Oxycodone may increase the anticoagulant activity of coumarin derivatives. Studies have not been performed to assess the effects of oxycodone on fertility.

Opioid analgesics cross the placenta. The use of oxycodone during labour may cause respiratory depression in the newborn infant. Water resources research born to opioid-dependent mothers may be physically dependent and suffer withdrawal symptoms water resources research, irritability, excessive crying, tremors, hyperactive reflexes, fever, vomiting, diarrhoea, sneezing and yawning).

Reproductive toxicity studies with oxycodone in animals have not been conducted. Oxycodone is excreted into human milk in low concentrations. Because of the possibility of adverse effects in water resources research infants (sedation, respiratory depression, withdrawal symptoms upon cessation of maternal administration), oxycodone is not recommended for breastfeeding mothers unless the expected benefits outweigh the potential risk. Patients should be cautioned accordingly. This medication may cause drowsiness.

In normal doses, the most common side effects of oxycodone are nausea, vomiting, constipation, drowsiness, unusual tiredness or weakness, vertigo, faintness, light-headedness, orthostatic hypotension and confusion. Less water resources research side effects include dry mouth, sweating, facial flushing, nervousness or restlessness. Raised intracranial pressure occurs in some patients. Due to the histamine releasing effect, allergic reactions such as urticaria and pruritus occur in some water resources research. Muscle rigidity has been reported following high doses.

Larger doses produce respiratory depression and hypotension, with circulatory failure and deepening coma. Convulsions may occur in infants and children. Death may occur from respiratory failure. Water resources research long-term use, physical and psychological dependence and tolerance may develop.



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