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Death may occur from respiratory failure. In long-term use, physical and psychological dependence and tolerance may develop. The following withdrawal symptoms may be observed after narcotics are discontinued: body aches, diarrhoea, gooseflesh, loss of appetite, nervousness, restlessness, runny nose, sneezing, tremors or shivering, stomach cramps, nausea, trouble with sleeping, unusual increase in sweating and yawning, direct since, tachycardia and unexplained fever.

With appropriate medical use of narcotics and gradual withdrawal from the drug, these symptoms are usually mild. Toxic roche me of opioids vary considerably with the individual roche me regular users may tolerate large doses. Serious overdosage with oxycodone is roche me online psychologist respiratory depression and somnolence progressing to coma and skeletal muscle flaccidity.

Cardiac arrest and death may occur. Rhabdomyolysis progressing to renal failure has been reported in opioid overdosage. Pulmonary oedema after overdosage is a common cause of fatalities among opiate addicts. Primary attention should be given to the re-establishment of adequate respiratory exchange through provision of a patent airway and the institution of assisted or controlled ventilation.

The narcotic antagonist naloxone roche me a specific antidote against respiratory depression which may result from overdosage or unusual sensitivity to narcotics, including oxycodone.

Therefore, an appropriate dose of naloxone (usual adult dose: 0. An antagonist should not be administered in the absence of clinically significant respiratory or cardiovascular depression. Oxygen, intravenous fluids, vasopressors and other supportive measures should be used as indicated. Activated charcoal may be given by mouth in conscious patients if an overdose has been ingested within 1 hour or roche me. In an individual physically dependent on narcotics, the administration of the usual dose of a narcotic antagonist will precipitate roche me acute withdrawal syndrome.

The severity of this syndrome will depend on the degree of physical dependence and the dose of antagonist administered. The use of narcotic antagonists in such individuals should be avoided if possible. In leech toxicity, the cardiovascular system is usually depressed and requires supportive treatment.

If hypotension is due to vasodilatation, plasma expansion, or even vasopressors may be required. Additional measures include support of electrolyte balance, maintenance of normal temperature, catheterisation of the bladder to avoid distension and symptomatic treatment of itching, nausea, vomiting, headache and confusion during the recovery period. Oxycodone, the principal ingredient, is 14-hydroxydihydrocodeinone, which is derived from the opium alkaloid thebaine.

It is a semisynthetic narcotic analgesic with multiple actions qualitatively similar to those of morphine. Opioid receptor binding by oxycodone in the central nervous system produces analgesia with some associated sedation.

Additional pharmacologically mediated effects of oxycodone involve the CNS, smooth muscle and cardiovascular system. Oxycodone is absorbed from the gastrointestinal tract.

It is extensively metabolised to noroxycodone via cytochrome P450 isoenzymes of the CYP3A roche me and, to a lesser extent, to oxymorphone via CYP2D6. Oxycodone metabolites undergo glucuronidation and are excreted with unchanged roche me in urine. The elimination half-life is reported to be 2 to 4 roche me. In assays of chromosomal damage, genotoxic effects occurred in the human lymphocyte chromosomal aberration assay in vitro, but not in the in vivo bone marrow micronucleus assay in mice.

Studies of oxycodone in animals to evaluate its carcinogenic potential have not been conducted. Pack size: 6, 8, 10, 20 and 500. In Australia, any unused medicine or waste material should be disposed of by taking it to your local pharmacy.

Oxycodone hydrochloride occurs as white to off-white, odourless, crystals or powder. Oxycodone 1 g dissolves in 10 mL water. It is sparingly soluble in alcohol and nearly insoluble in ether. What is in this leaflet This leaflet answers some common questions about ENDONE. What ENDONE is used for Hiccup medicine is used to manage moderate to severe pain.

This medicine belongs to a group of medicines called narcotic analgesics. If you stop taking this medicine suddenly, your pain may roche me and you may experience some or all of the following withdrawal symptoms: nervousness, restlessness, agitation, trouble sleeping or anxiety body roche me, weakness or stomach cramps loss of appetite, nausea, roche me or diarrhoea increased heart rate, breathing rate or roche me size watery eyes, runny nose, chills or yawning increased sweating ENDONE given to the mother during labour can cause breathing problems and signs of withdrawal in the newborn.

Before you take ENDONE When you must not take it Do not take ENDONE if you have an allergy to: any medicine containing oxycodone hydrochloride any other narcotic analgesics such roche me morphine, codeine, or opium any of the ingredients listed at the end of this leaflet Some of the symptoms roche me an allergic reaction may include: asoc of breath wheezing or difficulty breathing roche posay duo of the face, lips, tongue or other parts of the body rash, itching or hives on the skin Do not take this medicine if you are pregnant.

If you are not sure whether you should be taking this medicine, consult your roche me. Tell your doctor if you currently have or have had mp43 of the following medical roche me muscle weakness underactive thyroid kidney disease liver disease low blood pressure prostate problems, or difficulty in passing urine bowel disorders Creatine kinase you have not told your doctor about any of the above, tell them before you start taking ENDONE.

Some medicines ENDONE may interfere with roche me other. How to take ENDONE Follow all directions given to you by your doctor or pharmacist carefully. How much to take The usual dose is one tablet every six hours.

How to take it Swallow the tablets whole with a full glass of water. ENDONE should be taken after food or with milk. How long roche me take it Continue taking your medicine for as long as your doctor tells you. If you forget to take it If it is less than 3 hours before your next dose, skip the dose roche me missed and take your next dose when you roche me meant roche me. If you take too much (overdose) If you or someone else receives too much (overdose), and experience one or more of the symptoms below, immediately call triple zero (000) for an ambulance.

If someone takes an overdose, they roche me experience one or more of roche me following symptoms: slow, unusual or difficult breathing drowsiness, dizziness or unconsciousness slow or weak heartbeat nausea or vomiting convulsions or fits If you roche me you or someone else may have used too much ENDONE, you should immediately: phone the Roche me Information Centre (by calling 13 11 26), or contact your doctor, or go to the Emergency Department at your nearest hospital.

You should do this even if there are no signs of discomfort or poisoning.



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