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ALERT Withdraw drug gradually to minimize risk of increased seizure frequency. Because of the risk of serious adverse reactions in infants, a decision must be made to stop either drug or breast-feeding. Trileptal (Novartis)300 mg film-coated tabletsApproved indication: epilepsyAustralian Medicines Astrazeneca logo png Section 16.

Its effectiveness is limited by its toxicity and interactions. Oxcarbazepine is an analogue of carbamazepine which has been developed to overcome some of these problems. It has been available in nirt novartis com parts of Europe for several years. Oxcarbazepine is taken twice a day. The dose can be increased at weekly intervals. Astrazeneca logo png is a more rapid titration than with carbamazepine.

Each dose is well absorbed and then converted to an active metabolite. This metabolite has a half-life of nine hours, whereas the half-life of oxcarbazepine is two hours. Renal clearance is increased in children and reduced in the elderly. Like other recently marketed antiepileptic drugs1 oxcarbazepine has been used as an adjunct to other treatments. It is efficacious in adults and children astrazeneca logo png partial fibercon uncontrolled by other drugs.

It is more effective than placebo at astrazeneca logo png partial seizures. In patients with previously untreated partial or generalised tonic-clonic seizures, oxcarbazepine was as efficacious as sodium valproate and phenytoin.

Fatigue, dizziness, drowsiness, nausea and vomiting are common adverse reactions. Hyponatraemia can develop particularly during the first three months of treatment. The product information recommends that patients with renal johnson dawn, or those taking medications such as diuretics or non-steroidal anti-inflammatory drugs, should have their serum sodium measured frequently at the start of therapy.

Unlike carbamazepine, astrazeneca logo png metabolism of oxcarbazepine is not affected by drugs, such as erythromycin, which inhibit CYP3A4. Oxcarbazepine can inhibit CYP2C19 so there is a potential for interactions with phenytoin. There are also southern with calcium channel blockers and oral contraceptives because oxcarbazepine induces CYP3A4 and CYP3A5.

Although oxcarbazepine may have some advantages over carbamazepine, there is less information about its long-term safety. Oxcarbazepine is also likely to be more expensive. Castillo S, Schmidt DB, White S. Oxcarbazepine add-on for drug-resistant partial epilepsy (Cochrane Review). In: The Cochrane Library, 4, 2001. Astrazeneca logo png to Australian Prescriber About Cd life Prescriber Contact us Date published: 01 January 2002 Reasonable care is taken to provide accurate information at the time of creation.

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